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US 11,993,577 B2Granted
Synthesis of MDMA or its optically active (R)- or (S)-MDMA isomers
AssigneeEmpathBio, Inc.
InventorsMajed Fawaz, Nicholas Morra
Life of this patent
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Abstract
Provided herein is a process for the preparation of 3,4-methylenedioxymethamphetamine, (R)-3,4-methylenedioxymethamphetamine and (S)-3,4-methylenedioxymethamphetamine.
Claims32
A process for the preparation of 3,4-methylenedioxymethamphetamine, or a pharmaceutically acceptable salt thereof, the process comprising:
- i) preparing an organometallic reagent from a compound of Formula (I):
- wherein X is a halogen;
- R1 and R2 together with the atoms to which they are attached form a 1,3-dioxolane;
- ii) reacting the organometallic reagent of step i) with a compound of Formula (II):
- wherein R3 is alkyl;
- and
- iii) converting the product of step ii) to 3,4-methylenedioxymethamphetamine.
4 more elements
A process for the preparation of (R)-3,4-methylenedioxymethamphetamine, or a pharmaceutically acceptable salt thereof, the process comprising:
- i) preparing an organometallic reagent from a compound of Formula (I):
- wherein X is a halogen;
- R1 and R2 together with the atoms to which they are attached form a 1,3-dioxolane;
- ii) reacting the organometallic reagent of step i) with a compound of Formula (IIa):
- wherein R3 is alkyl;
- and
- iii) converting the product of step ii) to (R)-3,4-methylenedioxymethamphetamine.
4 more elements
A process for the preparation of (S)-3,4-methylenedioxymethamphetamine, or a pharmaceutically acceptable salt thereof, the process comprising:
- i) preparing an organometallic reagent from a compound of Formula (I):
- wherein X is a halogen;
- R1 and R2 together with the atoms to which they are attached form a 1,3-dioxolane;
- ii) reacting the organometallic reagent of step i) with a compound of Formula (II):
- wherein R3 is alkyl;
- and
- iii) converting the product of step ii) to (S)-3,4-methylenedioxymethamphetamine.
4 more elements
Dependencies are inferred from the claim text.