Cationic lipids
AssigneeTakeda Pharmaceutical Company Limited
InventorsSatoru Matsumoto, Yoshimasa Omori, Masahiro Mineno, Yasutaka Hoashi
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Abstract
The present invention provides a technique that enables introduction of active ingredients, in particular, nucleic acids, into cells with superior efficiency; and cationic lipids, etc., for use in the technique. The compound or a salt thereof according to the present invention is a compound represented by formula (I) or a salt thereof. In formula (I), n represents an integer of 2 to 5, R represents a linear C1-5 alkyl group, a linear C7-11 alkenyl group, or a linear C11 alkadienyl group, and wavy lines each independently represent a cis-bond or a trans-bond.
Claims8
A compound represented by formula (I):
- wherein:
- n represents an integer of 2 to 5;
- R represents a linear C1-5 alkyl group, a linear C7-11 alkenyl group, or a linear C11 alkadienyl group;
- and
- wavy lines each independently represent a cis-bond or a trans-bond, or a salt thereof.
3-((4-(Dimethylamino)butanoyl)oxy)-2,2-bis(((9Z)-tetradec-9-enoyloxy)methyl)propyl (9Z)-tetradec-9-enoate or a salt thereof.
3-((5-(Dimethylamino)pentanoyl)oxy)-2,2-bis(((9Z)-tetradec-9-enoyloxy)methyl)propyl (9Z)-tetradec-9-enoate or a salt thereof.
3-((6-(Dimethylamino)hexanoyl)oxy)-2,2-bis(((9Z)-tetradec-9-enoyloxy)methyl)propyl (9Z)-tetradec-9-enoate or a salt thereof.
Dependencies are inferred from the claim text.