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US 11,993,556 B1Granted
Peptoid-based inhibitors of the protein arginine methyltransferase (PRMT) family
AssigneeUniversity of North Florida Board of Trustees
InventorsBryan Knuckley, Corey P. Causey, Fatima Khwaja Rehman
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Abstract
Novel peptoid compounds, compositions and methods of using the compounds and compositions to inhibit protein arginine methyltransferase (PRMT) and induce apoptosis in cancer cells are presented.
Claims11
A method of inducing apoptosis in at least one cancer cell comprising:
- administering a therapeutically effective amount of a peptide mimetic to the at least one cancer cell wherein the peptide mimetic is a peptoid-based inhibitor of protein arginine methyltransferase (PRMT) comprising Formula (II)
- wherein R1 is at least one amine monomer;
- wherein R2 is at least one amine monomer;
- wherein X is a halogen;
- and
- wherein n is an integer between 1 and 4.
3 more elements
A method of inhibiting protein arginine methyltransferase (PRMT) in a patient in need thereof comprising:
- administering a therapeutically effective amount of a peptide mimetic to the patient wherein the peptide mimetic is a peptoid-based inhibitor of PRMT comprising Formula (I)
- wherein R1 is at least one amine monomer;
- wherein R2 is at least one amine monomer;
- wherein R3 is NH2 or CH2—X;
- wherein X is a halogen;
- and
- wherein n is an integer between 1 and 4.
4 more elements
Dependencies are inferred from the claim text.