Contact lens displaying improved vision attributes

A method of use of a first contact lens, comprising:

• applying to at least one eye of a subject the first contact lens that is a free radical reaction product of a reactive mixture comprising one or more polymerizable compounds suitable for making the contact lens and a high energy visible (HEV) light absorbing compound;
• and
• improving, by the contact lens, clarity of vision while driving at night when compared to a control lens that transmits at least 90 percent of light across the wavelength range of 400 to 409 nm, wherein the high energy visible light absorbing compound comprises a compound of formula I:
• wherein:
• m and n are independently 0, 1, 2, 3, or 4:
• T is a bond, O, or NR;
• Y is a linking group;
• Pg is a polymerizable group;
• R at each occurrence is independently H, C1-C6 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or Y—Pg;
• and
• R1 and R2, when present, are independently at each occurrence C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, C3-C7 cycloalkyl, aryl (preferably unsubstituted phenyl or phenyl substituted with alkyl or halo), halo, hydroxy, amino, NR3R4, or benzyl, wherein R3 and R4 are independently H or C1-C6 alkyl, or two adjacent R1 or R2 groups, together with the carbon atoms to which they are attached, combine to form a cycloalkyl or aryl ring.

A method of use of a first contact lens, comprising:

• applying to at least one eye of a subject the first contact lens that is a free radical reaction product of a reactive mixture comprising one or more polymerizable compounds suitable for making the contact lens and a high energy visible (HEV) light absorbing compound;
• and
• improving, by the first contact lens, overall preference of the first contact lens while using computer screens and digital devices as observed by the contact lens wearer when compared to a control lens that transmits at least 90 percent of light across the wavelength range of 400 to 409 nm, wherein the high energy visible light absorbing compound comprises a compound of formula I:
• wherein:
• m and n are independently 0, 1, 2, 3, or 4;
• T is a bond, O, or NR;
• Y is a linking group;
• Pg is a polymerizable group;
• R at each occurrence is independently H, C1-C6 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or Y—Pg;
• and
• R1 and R2, when present, are independently at each occurrence C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, C3-C7 cycloalkyl, aryl (preferably unsubstituted phenyl or phenyl substituted with alkyl or halo), halo, hydroxy, amino, NR3R4, or benzyl, wherein R3 and R4 are independently H or C1-C6 alkyl, or two adjacent R1 or R2 groups, together with the carbon atoms to which they are attached, combine to form a cycloalkyl or aryl ring.

A method of improving comfort at the end of the day by using a first contact lens applied to at least one eye of a subject, the method comprising:

• applying the first contact lens to at least one eye of the subject, wherein the first contact is a free radical reaction product of a reactive mixture comprising one or more polymerizable compounds suitable for making the contact lens and a high energy visible (HEV) light absorbing compound;
• and
• achieving, by the first contact lens, a least square means difference in contact lens user experience (“CLUE”) Comfort scale of approximately 3.9, the difference indicative of an improved comfort at the end of the day as measured by a contact lens user experience (“CLUE”) scale estimated across 1-week and 2-weeks of wear of the first contact lens and a control lens that transmits at least 90 percent of light across the wavelength range of 400 to 409 nm by the subject, wherein the high energy visible light absorbing compound comprises a compound of formula I:
• wherein:
• m and n are independently 0, 1, 2, 3, or 4;
• T is a bond, O, or NR;
• Y is a linking group;
• Pg is a polymerizable group;
• R at each occurrence is independently H, C1-C6 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or Y—Pg;
• and
• R1 and R2, when present, are independently at each occurrence C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, C3-C7 cycloalkyl, aryl (preferably unsubstituted phenyl or phenyl substituted with alkyl or halo), halo, hydroxy, amino, NR3R4, or benzyl, wherein R3 and R4 are independently H or C1-C6 alkyl, or two adjacent R1 or R2 groups, together with the carbon atoms to which they are attached, combine to form a cycloalkyl or aryl ring.

A method of use of a first contact lens, comprising:

• applying to at least one eye of a subject, the first contact lens that is a free radical reaction product of a reactive mixture comprising one or more polymerizable compounds suitable for making the contact lens and a high energy visible (HEV) light absorbing compound;
• and
• improving by at least 48.2%, by the first contact lens, comfort at the end of the day when compared to a control lens that transmits at least 90 percent of light across the wavelength range of 400 to 409 nm, wherein the high energy visible light absorbing compound comprises a compound of formula I:
• wherein:
• m and n are independently 0, 1, 2, 3, or 4;
• T is a bond, O, or NR;
• Y is a linking group;
• Pg is a polymerizable group;
• R at each occurrence is independently H, C1-C6 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or Y—Pg;
• and
• R1 and R2, when present, are independently at each occurrence C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, C3-C7 cycloalkyl, aryl (preferably unsubstituted phenyl or phenyl substituted with alkyl or halo), halo, hydroxy, amino, NR3R4, or benzyl, wherein R3 and R4 are independently H or C1-C6 alkyl, or two adjacent R1 or R2 groups, together with the carbon atoms to which they are attached, combine to form a cycloalkyl or aryl ring.

A method of use of a first contact lens, comprising:

• applying to at least one eye of a subject the first contact lens that is a free radical reaction product of a reactive mixture comprising one or more polymerizable compounds suitable for making the contact lens and a high energy visible (HEV) light absorbing compound;
• and
• improving by approximately 1.68 times, by the contact lens, clarity of vision while driving at night when compared to a control lens that transmits at least 90 percent of light across the wavelength range of 400 to 409 nm, wherein the high energy visible light absorbing compound comprises a compound of formula I:
• wherein:
• m and n are independently 0, 1, 2, 3, or 4;
• T is a bond, O, or NR;
• Y is a linking group;
• Pg is a polymerizable group;
• R at each occurrence is independently H, C1-C6 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or Y—Pg;
• and
• R1 and R2, when present, are independently at each occurrence C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, C3-C7 cycloalkyl, aryl (preferably unsubstituted phenyl or phenyl substituted with alkyl or halo), halo, hydroxy, amino, NR3R4, or benzyl, wherein R3 and R4 are independently H or C1-C6 alkyl, or two adjacent R1 or R2 groups, together with the carbon atoms to which they are attached, combine to form a cycloalkyl or aryl ring.

A method of use of a first contact lens, comprising:

• applying to at least one eye of a subject the first contact lens that is a free radical reaction product of a reactive mixture comprising one or more polymerizable compounds suitable for making the contact lens and a high energy visible (HEV) light absorbing compound;
• and
• improving by at least 105%, by the first contact lens, overall preference of the first contact lens while using computer screens and digital devices as observed by the contact lens wearer when compared to a control lens that transmits at least 90 percent of light across the wavelength range of 400 to 409 nm, wherein the high energy visible light absorbing compound comprises a compound of formula I:
• wherein:
• m and n are independently 0, 1, 2, 3, or 4;
• T is a bond, O, or NR;
• Y is a linking group;
• Pg is a polymerizable group;
• R at each occurrence is independently H, C1-C6 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or Y—Pg;
• and
• R1 and R2, when present, are independently at each occurrence C1-C6 alkyl, C1-C6 alkoxy, C1-C6, thioalkyl, C3-C7 cycloalkyl, aryl (preferably unsubstituted phenyl or phenyl substituted with alkyl or halo), halo, hydroxy, amino, NR3R4, or benzyl, wherein R3 and R4 are independently H or C1-C6 alkyl, or two adjacent R1 or R2 groups, together with the carbon atoms to which they are attached, combine to form a cycloalkyl or aryl ring.