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US 11,992,576 B2Granted
Embolic compositions and methods
AssigneeArsenal Medical, Inc.
InventorsJeffrey Groom, Craig Wiltsey, Quynh Pham, Nikhita Mansukhani, Courtney Guertin, Lee Core, Upma Sharma
Life of this patent
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Abstract
The present disclosure pertains to crosslinkable compositions and systems as well as methods for forming crosslinked compositions in situ, including the use of the same for embolizing vasculature including the neurovasculature within a patient, among many other uses.
Claims29
A kit for forming crosslinkable compositions for vascular embolization, said kit comprising:
- (a) a first fluid composition comprising a first polysiloxane having two or more unsaturated groups and a first imaging agent,
- (b) a second fluid composition that comprises a first hydride material having two or more hydride groups and a second imaging agent which is the same or different from the first imaging agent,
- (c) a dry composition comprising a first silica filler and optionally a second silica filler which is the same or different from the first silica filler, and
- wherein the first fluid composition, second fluid composition, and dry composition are stable, and when mixed, form a crosslinkable composition having the first and second imaging agents substantially evenly dispersed in the crosslinkable composition;
- and
- wherein the crosslinkable composition cures into a solid when injected into a target vessel and occludes the target vessel.
3 more elements
A method comprising
- (a) forming a crosslinkable composition for vascular embolization comprising:
- annealing a first fluid composition comprising a first polysiloxane having two or more unsaturated groups and a first imaging agent, annealing a second fluid composition comprising a hydride material having two or more hydride groups and a second imaging agent that is the same or different from the first imaging agent, and at the time of use, mixing the first and second fluid compositions with a dry composition comprising a first silica filler and optionally a second silica filler that is the same or different from the first silica filler to form the crosslinkable composition, wherein the first and second imaging agents are substantially evenly dispersed in the crosslinkable composition and
- (b) injecting the crosslinkable composition into the vasculature of a patient whereupon the crosslinkable composition crosslinks and forms a solid which occludes a target vessel into which it is injected.
Dependencies are inferred from the claim text.