Back to results
US 11,992,575 B2Granted
Radioactive liquid embolic
AssigneeMicroVention, Inc.
InventorsGregory M. Cruise, Xinping Wu, Matthew J. Fitz, Yue Wu
Life of this patent
Estimating the term…
Abstract
Liquid embolic preparations and medical treatment methods of using those preparations are described. In some embodiments, the preparations or solutions can transition from a liquid to a solid for use in the embolization. The preparations can include biocompatible polymers with covalently bound radioactive iodine isotopes.
Claims13
A polymeric composition, comprising a non-physiological solution, and a folate-polymer conjugate that is a reaction product of:
- 1) A biocompatible polymer comprising a reaction product of:
- a first monomer including a polymerizable moiety having a biodegradable linkage to a visualization agent having at least one aromatic ring, wherein the at least one aromatic ring includes at least one iodine atom, wherein at least one of the at least one iodine atom is a radioactive isotope,
- and a second monomer comprising hydroxyethyl methacrylate;
- and
- 2) A folate compound having the formula:
- wherein n is 0-100;
- wherein the folate compound is conjugated to the hydroxy moiety of the hydroxyethyl methacrylate;
- wherein the folate-polymer conjugate is soluble in the non-physiological solution and insoluble in a physiological solution;
- and
- wherein the folate-polymer conjugate comprises the formula:
- wherein n is 0-100.
8 more elements
A polymeric composition, comprising a non-physiological solution and a folate-polymer conjugate, wherein:
- the folate-polymer conjugate comprises a visualization agent having at least one aromatic ring, wherein the at least one aromatic ring includes at least one iodine atom, wherein at least one of the at least one iodine atom is a radioactive isotope,
- the folate-polymer conjugate comprises the formula:
- wherein n is 0-100;
- and
- the folate-polymer conjugate is soluble in the non-physiological solution and insoluble in a physiological solution.
2 more elements
Dependencies are inferred from the claim text.