Percutaneous absorption preparation for treating dementia comprising donepezil

A percutaneous absorption preparation for the treatment of dementia comprising a backing layer, a drug-containing layer, and a release liner,

• wherein the drug-containing layer of the percutaneous absorption preparation comprises (a) donepezil or a pharmaceutically acceptable salt thereof as an active component, (b) a propylene glycol monocaprylate as a solubilizer, (c) a styrene-isoprene-styrene block copolymer as an adhesive, and (d) a plasticizer,
• wherein a ratio of donepezil or the pharmaceutically acceptable salt thereof:
• the propylene glycol monocaprylate is not less than 1:1.5 by weight,
• wherein the styrene-isoprene-styrene block copolymer makes up 10-70 wt % of a total weight of the drug-containing layer, and
• wherein the plasticizer (d) is selected from the group consisting of paraffin process oil, naphthalene process oil, aromatic process oil, olive oil, camellia oil, tall oil, castor oil, isopropyl myristate, hexyl lauric acid, mineral oil, octyldodecyl myristate, propylene glycol, and a combination thereof.