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AssigneeAlma Mater Studiorum - Università di Bologna
InventorsLaura Calza, Luciana Giardino, Maria Letizia Focarete, Chiara Gualandi, Maria-Laura Bolognesi, Nadia Passerini, Giampiero Pagliuca, Teresa Gazzotti, Elisa Zironi
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The present invention relates to electro spun fibers for a local release in the central nervous system of an anti-inflammatory and a promyelinating agent over a defined time-window, in order to limit secondary neurodegeneration triggered by the glutamate release and supported by on-going inflammation. The combined treatment aimed to reduce inflammation and improve remyelination in the very early stage of the pathology improving the chronic clinical outcome of the lesion. In particular the present invention relates to electrospun polymeric fibers, wherein said fibers are loaded with 3,3,5-Triiodo-L-thyronine (T3) and Ibuprofen.
Electrospun polymeric fibers in the form of scaffold, wherein part or all of said fibers are loaded with the promyelinating agent 3,3,5-Triiodo-L-thyronine (T3) and another part or all of said fibers are loaded with an anti-inflammatory agent, for a local release of said promyelinating agent and said anti-inflammatory agent in a method of treating a spinal cord injury, wherein said electrospun polymeric fibers are suitable to be implanted directly on top of a lesion, wherein the local release of said promyelinating agent and said anti-inflammatory agent in a method of treating a spinal cord injury occurs over an estimated time of 8 to 14 days.
Dependencies are inferred from the claim text.