Collagenase loaded liposomes for enhancing drug delivery
AssigneeTechnion Research & Development Foundation Limited
InventorsAvi Schroeder, Assaf Zinger
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Abstract
Pharmaceutical compositions comprising at least one lipid-based particle encapsulating a proteolytic enzyme and a pharmaceutically acceptable carrier, wherein the proteolytic enzyme comprises at least 75% proteolytically active enzyme are provided. Methods of using same and producing same are also provided.
Claims20
A pharmaceutical composition formulated for administration to a human comprising at least one lipid-based particle encapsulating at least one proteolytic enzyme in solution and a pharmaceutically acceptable carrier, wherein at least 75% of said proteolytic enzyme is proteolytically active and wherein said solution comprises a pH from 8 to 10.
A method of producing a pharmaceutical composition comprising a liposome encapsulating at least one proteolytic enzyme, the method comprising:
- a. providing a thin lipid film;
- and
- b. rehydrating said thin lipid film with a solution comprising said proteolytic enzyme, wherein said rehydrating produces liposomes encapsulating said proteolytic enzyme wherein at least 75% of said proteolytic enzyme is proteolytically active and wherein said solution comprises a pH from 8 to 10;
- thereby producing liposomes encapsulating at least one enzyme.
A pharmaceutical composition formulated for administration to a human comprising at least one lipid-based particle encapsulating collagenase in solution and a pharmaceutically acceptable carrier, wherein at least 75% of said collagenase is proteolytically active and wherein said solution comprises a pH from 8 to 10.
Dependencies are inferred from the claim text.