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US 11,992,556 B2Granted
Pharmaceutical aerosol product for administration by oral or nasal inhalation
AssigneeCovis Pharma GmbH
InventorsHelgert Müller, Renate Engelstätter, Ulrich Bildmann, Andrea Bauer, Paul McGlynn
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Abstract
This invention relates to a pharmaceutical aerosol product suitable for administration by oral or nasal inhalation and its use in the treatment of respiratory diseases, in particular in the treatment of children. The aerosol composition comprises ciclesonide, ethanol and either 1, 1, 1, 2-tetrafluoroethane, or 1, 1, 1, 2, 3, 3, 3-heptafluoropropane.
Claims12
A method for preparing a pharmaceutical composition, the method comprising:
- combining:
- (a) ciclesonide,
- (b) a propellant selected from 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3,3-heptafluoropropane and a mixture thereof, and
- (c) ethanol in an amount effective to solubilize the ciclesonide and
- (d) optionally a surfactant,
- wherein the concentration of ciclesonide in the composition is from 0.1 to 0.8 mg per ml, wherein the pharmaceutical composition is contained in an aerosol canister equipped with a metering valve.
3 more elements
Dependencies are inferred from the claim text.