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US 11,992,533 B2Granted
Methods of treatment of HLA-B27 related inflammatory diseases and compositions related to same
AssigneeMichael Stalhamer
InventorsIrun Cohen, Denis Ravel, Raanan Margalit, Binah Baum
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Abstract
The present disclosure provides methods and compositions for treatment of an HLA-B27-associated autoimmune inflammatory disorder by administration of nucleic acid encoding HSP90 or an active fragment thereof.
Claims20
A method of treating or preventing a spondyloarthropathy in a subject having, or at risk of developing, the spondyloarthropathy, the method comprising:
- provided that the subject is HLA-B27 positive, administering to said subject a composition comprising a nucleic acid molecule encoding a mammalian heat shock protein 90 (HSP90), or an active fragment thereof, wherein the nucleic acid molecule is operatively linked to one or more transcription control sequences.
Dependencies are inferred from the claim text.