Extracellular vesicles for vaccine delivery
AssigneeLonza Sales AG
InventorsRaymond J. Moniz, Russell E. McConnell, Nikki Ross, Christine McCoy, Timothy J. Soos, Ke Xu
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Abstract
The present disclosure relates to extracellular vesicles (EVs), e.g., exosomes, comprising a payload (e.g., an antigen, adjuvant, and/or immune modulator) and/or a targeting moiety. Also provided herein are methods for producing the EVs (e.g., exosomes) and methods for using the EVs (e.g., exosomes) to treat and/or prevent diseases or disorders, e.g., cancer, graft-versus-host disease (GvHD), autoimmune disease, infectious diseases, or fibrotic diseases.
Claims20
An isolated extracellular vesicle (EV) having an exterior surface and a luminal surface and comprising (i) an antigen, (ii) a Scaffold X moiety, and (iii) a Scaffold Y moiety, wherein the antigen is fused to the Scaffold X moiety or the Scaffold Y moiety.
An isolated extracellular vesicle (EV) having an exterior surface and a luminal surface and comprising (i) a first antigen, (ii) a second antigen, and (iii) a third antigen, wherein the first antigen, the second antigen, and/or the third antigen is fused to a Scaffold X moiety or a Scaffold Y moiety.
Dependencies are inferred from the claim text.