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US 11,992,523 B2Granted
Method for producing chikungunya virus (CHIKV) virus-like particles comprising the C, E2, and E1 structural proteins
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsGary J. Nabel, Wataru Akahata, Srinivas Rao
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Abstract
The invention features compositions and methods for the prevention or treatment of one or more strains of Chikungunya virus, as well as other alphavirus-mediated diseases.
Claims4
A method for producing a virus-like particle, comprising:
- expressing in a cell one or more polynucleotides encoding Chikungunya virus (CHIKV) strain 37997 structural proteins under conditions for self-assembly of the CHIKV strain 37997 structural proteins to form a virus-like particle, wherein the CHIKV strain 37997 structural proteins comprise at least CHIKV capsid (C) protein, CHIKV E2 protein, and CHIKV E1 protein, and
- wherein the cell does not express polynucleotides encoding CHIKV non-structural proteins.
Dependencies are inferred from the claim text.