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OwnerAlaina Ingebritson, Axel Neubauer +2inventors
InventorsAlaina Ingebritson, Axel Neubauer, Hilda Elizabeth Smith, Astrid De Greeff
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The invention relates to bacterial infections, vaccines directed against those infections and bacterial vaccines. More particularly, the invention relates to vaccines directed against Streptococcus infections in pigs. The invention provides a ΔFolT mutant of a bacterium having reduced capacity to transport folate, wherein said capacity has been reduced by functionally deleting folate transporter (FolT) function. The invention also provides a method to reduce virulence of a bacterium comprising reducing the capacity of said bacterium to transport folate.
A method to reduce virulence of a Streptococcus suis (S. suis) bacterium comprising reducing the capacity of said bacterium to transport folate compared to wild type;
A method of treating Streptococcus infection in swine comprising administering a composition comprising a recombinant ΔFolT mutant of a Streptococcus suis (S. suis) bacterium having reduced capacity to transport folate compared to wild type, wherein said capacity has been reduced by deletion or inactivation of a gene of the S. suis encoding folate transporter (FolT) function.
Dependencies are inferred from the claim text.