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US 11,992,516 B2Granted
Compositions comprising IL-15-based molecules and immune checkpoint inhibitor antibodies
AssigneeAltor BioScience Corporation
InventorsBai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
Life of this patent
Estimating the term…
Abstract
The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
Claims10
A composition comprising:
- synergistically effective amounts of an immune checkpoint inhibitor antibody and an IL-15N72D:IL-15RαSu/Fc complex (ALT-803), wherein the immune checkpoint inhibitor antibody is a CTLA-4, PD-1, or PD-L1 antibody, wherein said ALT-803 comprises a dimeric IL-15RaSu/Fc and two IL-15N72D molecules, wherein the composition is formulated for administration to a human subject suffering from a neoplasia comprising the immune checkpoint molecule targeted by the antibody, and wherein the amounts are synergistically effective for treatment of said neoplasia.
Dependencies are inferred from the claim text.