US 11,992,508 B2 · Micronized eggshell membrane particles and the use thereof to promote the healing of wounds

Abstract

The invention provides a particle consisting essentially of micronized ESM and having a mean particle diameter of less than 100 μm for use in promoting the healing of a chronic wound at risk of, or in which there is, (i) an inappropriate level of matrix-metalloproteinase (MMP) activity against extracellular matrix (ECM) proteins and/or peptide growth or differentiation factors, and/or (ii) an excessive inflammatory response. The invention further provides pharmaceutical compositions, wound dressings and implantable medical devices comprising the micronized ESM-containing particles for use in said treatments. The invention still further provides methods for manufacturing the micronized ESM-containing particles and the compositions, dressings and implantable medical devices comprising the same.

Claims13

Dependent claims

A method of promoting the healing of a non-healing chronic wound, wherein the non-healing chronic wound healing,

(i) has not healed in 30 days after wound formation, and
(ii) is stalled in the inflammatory stage of wound healing,
wherein said method consists of applying directly to the surface or interior of the non-healing chronic wound a particle consisting of micronized egg shell membrane (ESM) having a mean particle diameter of equal to or less than 80 μm and being essentially insoluble in water at a neutral pH, and
wherein the application of the particle to the non-healing chronic wound causes the non-healing chronic wounds to progress through the healing stages.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

15/522,441Filed 28 Oct 2015

Priority

GB 141918328 Oct 2014

Published

US 2017/0319629 A19 Nov 2017

Granted

28 May 2024

Term ends

Not estimatedThe source records don’t support an estimate.

Classification20 codes

A61K 35/57
Materials from animals other than mammals: birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
A61K 9/14
Medicinal preparations characterised by special physical form: particulate form, e.g. powders, Processes for size reducing of pure drugs or the…
A61L 15/40
Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons: containing ingredients of…
A61L 15/60
Use of materials characterised by their function or physical properties: liquid-swellable gel-forming materials, e.g. super-absorbents

Micronized eggshell membrane particles and the use thereof to promote the healing of wounds

Life of this patent

Micronized eggshell membrane particles and the use thereof to promote the healing of wounds

Life of this patent

Abstract

Claims13