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US 11,992,483 B2Granted
Emulsions for local anesthetics
AssigneeCali Biosciences US, LLC
InventorsAndrew Xian Chen, Lijia Chen, Damian McLoud
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Abstract
Use of an emulsion for pain relief comprising a local anesthetic, lecithin, oil and an aqueous phase, wherein local anesthetic is non-covalent bound to the emulsion oil droplets and the emulsion is physically and chemically stable and said emulsion provides better safety, extended release pharmacokinetics and a prolonged duration of action of the local anesthetic.
Claims26
A method for relief of a pain in a subject in need thereof, the method comprising:
- administering to the subject an effective amount of a water-in-oil emulsion composition, comprising:
- an amide local anesthetic, which is ropivacaine, a pharmaceutically acceptable salt thereof or a combination thereof, wherein the amide local anesthetic is no more than about 4% by weight of the emulsion;
- an oil phase, the oil phase comprising lecithin and a vegetable oil at a weight ratio between 2:1 to 5:4;
- and
- a water-miscible organic solvent between 6% and 10% of the emulsion weight;
- an aqueous phase, where the water content is less than 5% of the emulsion weight, wherein small water droplets are dispersed in the oil phase and
- the emulsion contains particles or water droplets with a diameter between about 30 nm and about 500 nm.
4 more elements
Dependencies are inferred from the claim text.