Malleable controlled release local anesthetic with hemostatic composition

A malleable sustained release formulation designed for packing and sticking in a dental extraction cavity, a surgical cavity or a wound cavity of a patient, the formulation comprising:

• a homogenous dry blend including
• a. a local anesthetic formulated into sustained release microparticles of a size between 0.1 and 100 microns, the microparticles encapsulating the local anesthetic for forming a primary sustained release vehicle for the local anesthetic by diffusion from the microparticles, and
• b. a gelatin powder, wherein the gelatin is selected from the group consisting of a bovine skin hemostatic agent and porcine skin hemostatic agent and having a Bloom value of about 200 to about 400;
• and
• an aqueous solution in an amount of about 1.5 to about 10 parts by weight to about 1 part by weight of the gelatin powder within the dry blend,
• wherein the gelatin powder and the aqueous solution form a gelled matrix with the local anesthetic sustained release microparticles incorporated into and suspended within the gelled matrix such that the gelled matrix comprises a secondary sustained release vehicle for the local anesthetic microparticles by diffusion through the matrix, and
• wherein the gelled matrix is present in an amount of about 1 to about 7 parts by weight to 1 part by weight of the local anesthetic microparticles such that the gelled matrix with the local anesthetic microparticles suspended therein is a malleable putty prior to its insertion into the cavity of a patient such that a bolus of the malleable formulation can be mixed by hand under low shear ambient conditions for molding a bolus manually sized and shaped to fit the cavity and be retained therein.