Compositions and methods for enhancing the efficacy of contraceptive microbicides
AssigneeEvofem, Inc.
InventorWendell Guthrie
Life of this patent
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Abstract
The present disclosure relates to compositions and methods for contraception that also enhance the efficacy of microbicides. Such compositions serve the dual purpose of preventing pregnancy and lessening the risk of spreading sexually transmitted diseases. More specifically, the compositions and methods relate to syngergistic contraceptive microbicide and antiviral compositions comprising a combination of a contraceptive microbicide and an antiviral agent in an acidic carrier that enhances the efficacy of both the contraceptive microbicide and antiviral agent.
Claims18
A method for preventing pregnancy comprising intravaginally administering a composition to a subject in need thereof, wherein the composition comprises:
- a) a matrix-forming compound selected from the group consisting of:
- alginic acid, chitosan, gellan gum, and poloxamer;
- b) a bioadhesive compound that is the same or different from the matrix-forming compound;
- c) L-lactic acid;
- and d) an aqueous-based pharmaceutically acceptable carrier, wherein the composition has a nonmatrix state when not in contact with ejaculate, and a matrix state when in contact with ejaculate, and wherein the total lactic acid in the composition is not in a form of racemic mixture.
Dependencies are inferred from the claim text.