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US 11,992,469 B2Granted
Targeting mitochondrial dynamics by mitochondrial fusion promoter M1 as a treatment strategy for nervous system injury
AssigneeCity University of Hong Kong
InventorsChi Him Eddie Ma, Ngan Pan Bennett Au
Life of this patent
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Abstract
Provided herein are methods of treating a nerve injury in a subject in need thereof and methods of treating an injured neuron using diaryl hydrazones.
Claims19
A method of treating a nerve injury in a subject in need thereof, the method comprising administering a therapeutically effective amount of a compound to the subject, wherein the compound has Formula I:
- or a conjugate salt thereof, wherein
- m is a whole number selected from 1-4;
- n is a whole number selected from 1-4;
- R1 and R2 for each instance is independently selected from the group consisting of halide, nitrite, nitro, phosphate, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, aralkyl, heteroaryl, —OR, —SR, and —NR2;
- R3 is C1-C6 alkyl;
- R4 is hydrogen or alkyl;
- and
- R for each instance is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, aralkyl, and heteroaryl.
5 more elements
A method of treating an injured neuron, the method comprising contacting the injured neuron with a compound, wherein the compound has Formula I:
- or a conjugate salt thereof, wherein
- m is a whole number selected from 1-4;
- n is a whole number selected from 1-4;
- R1 and R2 for each instance is independently selected from the group consisting of halide, nitrile, nitro, phosphate, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, aralkyl, heteroaryl, —OR, —SR, and —NR2;
- R3 is C1-C6 alkyl;
- R4 is hydrogen or allyl;
- and
- R for each instance is independently selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, aralkyl, and heteroaryl, wherein the step of contacting the injured neuron occurs in vitro or ex vivo.
5 more elements
Dependencies are inferred from the claim text.