Method for chromatographic purification of viscous loads

A method for purifying a mixture to be separated, in a multicolumn chromatography system that comprises a plurality of columns and intercolumn fluidic links, the method comprising successively and cyclically:—a step of collecting a raffinate, a step of injecting the mixture to be separated into the multicolumn chromatography system, a step of collecting an extract and a step of injecting eluent into the multicolumn chromatography system, at an operating temperature;

• wherein the method comprises moving a fluid through the intercolumn fluidic links at a velocity greater than 0.5 m/s;
• wherein the mixture to be separated has a viscosity at 20° C. greater than or equal to 3 mPa·s;
• and wherein a dry matter mass concentration of the mixture to be separated is equal, within 5%, to a threshold concentration, said threshold concentration being such that:—a first viscosity of the mixture to be separated, at a second dry matter mass concentration equal to the threshold concentration and at the operating temperature, is equal to twice a second viscosity of the mixture to be separated, at a dry matter mass concentration equal to 85% of the threshold concentration and at the operating temperature.