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US 11,987,601 B2Granted
Norovirus fusion proteins and VLPs comprising norovirus fusion proteins
AssigneeAramis Biotechnologies Inc.
InventorsPierre-Olivier Lavoie, Marc-Andre D'Aoust
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Abstract
Nucleic acids encoding norovirus VP1 fusion proteins and VLPs comprising the norovirus VP1 fusion proteins are provided. Methods for norovirus VP1 fusion protein and norovirus VLP production in plants are also described. The VP1 fusion protein comprises, a first sequence encoding an S domain derived from a first norovirus strain, and a second sequence encoding a P domain derived from a second norovirus strain.
Claims20
A method of producing a norovirus VP1 fusion protein in a plant, a portion of the plant, or a plant cell comprising,
- introducing into the plant, the portion of the plant, or the plant cell a nucleic acid comprising a first sequence encoding an S domain derived from a first norovirus strain and a second sequence encoding a P domain derived from a second norovirus strain, the first norovirus strain selected from norovirus genotypes GI.1, GI.5, GII.1, GII.12, GII.14, and GII.21, and the second norovirus strain selected from norovirus genogroups GI, and GIV or selected from norovirus genotypes GII.1, GII.2, GII.3, GII.4, GII.5, GII.7, GII.12, GII.13, GII.14, GII.17 and GII.21, and
- incubating the plant, the portion of the plant, or the plant cell under conditions that permit the expression and production of the norovirus VP1 fusion protein.
Dependencies are inferred from the claim text.