Diagnostic system

An integrated diagnostic cartridge, comprising:

• a loading module;
• a lysis module;
• a purification module comprising a rotary valve comprising:
• a. a stator comprising a stator face and a plurality of passages, each passage comprising a port at the stator face;
• b. a rotor operably connected to the stator and comprising a rotational axis, a rotor valving face, and a flow channel having an inlet and an outlet at the rotor valving face;
• c. a retention element biasing the stator and the rotor together at a rotor-stator interface to form a fluid tight seal;
• d. a gasket interposed between the stator face and the rotor valving face having a pair of openings in fluidic communication with the flow channel inlet and the flow channel outlet;
• a reaction module,
• wherein the loading module is in fluidic communication with the lysis module and the purification module is in fluidic communication with the reaction module;
• and
• the rotary valve further comprising a storage configuration and an operational configuration wherein in the operational configuration the gasket forms a fluid tight seal between the stator face and the rotor valving face.