Mumps virus as a potential oncolytic agent
AssigneeMayo Foundation for Medical Education and Research
InventorsMark J. Federspiel, Arun Ammayappan, Gennett Pike, Stephen James Russell
Life of this patent
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Abstract
This document relates to methods and materials for virotherapy. For example, this document provides methods and materials for treating cancer using a recombinant mumps virus as an oncolytic agent.
Claims18
A recombinant mumps virus (MuV) having oncolytic anti-cancer activity, wherein said recombinant MuV comprises nucleic acid encoding an RNA polymerase large (L) subunit protein comprising a N to H substitution at amino acid 1631 as numbered in SEQ ID NO:10.
A method for treating a patient having cancer, wherein said method comprises administering to said patient a recombinant mumps virus (MuV) having oncolytic anti-cancer activity, wherein said recombinant MuV comprises nucleic acid encoding an RNA polymerase large (L) subunit protein comprising a N to H substitution at amino acid 1631 as numbered in SEQ ID NO:10.
Dependencies are inferred from the claim text.