Mapping brain perivascular spaces

A system for mapping brain perivascular spaces using clinical data, comprising:

• a memory to store one or more images of a brain of a patient;
• a processor coupled to the memory and configured to:
• obtain a combined image of the brain of the patient, the combined image generated by combining a first image and a second image of the brain of the patient, the first image including a first contrast, the second image including a second contrast, the combined image including a third contrast, the third contrast being higher than the first contrast and the second contrast,
• determine the brain perivascular spaces within the combined image of the brain of the patient, and
• generate a three-dimensional (3-D) map of the brain perivascular spaces;
• and
• a display configured to display or render an image of the brain perivascular spaces of the brain of the patient to an operator.

A method for analyzing brain perivascular spaces, comprising:

• obtaining a first image of a brain of a patient, the first image including a first contrast;
• obtaining a second image of the brain of the patient, the second image including a second contrast;
• combining the first image and the second image to form a combined image, the combined image preserving and magnify structures including the brain perivascular spaces within the brain of the patient, the combined image including a third contrast, the third contrast being higher than the first contrast and the second contrast;
• determining the brain perivascular spaces within the combined image of the brain of the patient;
• determining fluid characteristics within the brain;
• generating a map of the brain perivascular spaces along with fluid characteristics within the brain of the patient;
• and
• displaying the map of the brain perivascular spaces along with the fluid characteristics within the brain of the patient.