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US 11,906,524 B2Granted
Urea biosensors and uses thereof
AssigneeDuke University
InventorsHomme W. Hellinga, Malin J. Allert
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Abstract
The present subject matter provides urea biosensors as well as compositions, devices, and methods comprising such biosensors.
Claims13
A biosensor for urea, comprising a urea-binding protein and a reporter group, wherein said urea-binding protein is at least 90% identical to SEQ ID NO:
- 18 and comprises primary complementary surface amino acids (PCS), wherein said PCS comprises residues selected from the group consisting of 92S, 111Y, 114Q, 157Y, 211N and 238S, and wherein said reporter group comprises a fluorophore and is functional to transduce a detectable signal when said biosensor binds to urea.
Dependencies are inferred from the claim text.