Methods and compositions for treating diseases associated with exhausted T cells
AssigneeThe Trustees of the University of Pennsylvania
InventorsE. John Wherry, Bertram Bengsch, Omar Khan, Jennifer Wu, Josephine Giles
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Abstract
The present invention provides compositions and methods for detecting exhausted T cells in a subject. The present invention also provides methods for treating a subject having a disease characterized by the presence of exhausted T cells or certain subpopulations thereof.
Claims2
A method for detecting exhausted T cells in a subject, wherein the method comprises
- detecting an OCR footprint in T cells from the subject, wherein the OCR footprint is correlated with exhausted T cells, and wherein said OCR footprint in said T cells from the subject is determined by a method comprising conducting quantitative PCR (qPCR) on a chromatin library from said population of T cells from the subject, and conducting high-throughput array-based testing on amplification products of said qPCR.
A method for detecting exhausted T cells in a subject, wherein the method comprises detecting an OCR footprint in T cells from the subject, wherein the OCR footprint is correlated with exhausted T cells, and wherein said OCR footprint in said T cells from the subject is determined by a method comprising conducting quantitative PCR (qPCR) on a chromatin library from said population of T cells from the subject, and conducting multi-locus qPCR testing.
Dependencies are inferred from the claim text.