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US 11,906,454 B2Granted
Highly sensitive microcalorimeters for cellular bioenergetics
AssigneePresident and Fellows of Harvard College
InventorsJinhye Bae, Joost J Vlassak
Life of this patent
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Abstract
A microcalorimeter device capable of measuring cellular bioenergetics and systems that are limited in analytic volume. The microcalorimeter device provides sub-nWatt resolution and even tens of pico-Watt resolution, thus enabling resolution of the metabolic rate of a single cell.
Claims10
A device for quantitatively measuring the metabolic rate of a single cell comprising:
- a highly sensitive thermopile-based microcalorimetric sensor further comprising a plurality of individual sensor elements, wherein each individual sensor element comprises a membrane and a combination of at least one heating element and at least one thermopile disposed on the same membrane,
- wherein the thermopile is fabricated of a material selected from a combination of a first alloy of Copper and Nickel and a second alloy of Nickel and Chrome, or a combination of the first alloy and a third alloy of Nickel and Chrome, the thermopile-based microcalorimetric sensor provides sub nano-Watt resolution, and the sub nano-Watt resolution measures energy production and consumption in the single cell in real time.
Dependencies are inferred from the claim text.