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US 11,898,210 B2Granted
Tools for assessing FimH blockers therapeutic efficiency
AssigneeEnterome S.A.
InventorsAlessandra Cervino, Christophe Bonny, Jonathan Plassais
Life of this patent
Estimating the term…
Abstract
The present invention relates to an in vitro method for identifying subjects hosting high amounts of Fim H expressing proteobacteria in their gut, said method comprising the step of detecting the expression of the fimH gene in a stool sample of said subjects.
Claims8
A method for treating a human subject suffering from Crohn Disease (CD), said method comprising the steps of:
- a) isolating a nucleotide fraction of a stool sample from said subject,
- b) detecting expression of the fimH gene in said nucleotide fraction by measuring the switch of the Escherichia coli fim operon transcription from OFF to ON in a nucleotide fraction of said stool sample to calculate an ON/(ON+OFF) ratio of the fimH gene, and comparing the ON/(ON+OFF) ratio with a reference value of 15%,
- c) administering a mannose derivative FimH blocker to subjects whose nucleotide fraction has an ON/(ON+OFF) ratio higher than said reference value of 15%.
Dependencies are inferred from the claim text.