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US 11,897,970 B2Granted
Antibacterial products
AssigneeThe University of Liverpool
InventorsIshwar Singh, Edward Taylor
Life of this patent
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Abstract
The invention provides novel antibacterial compounds of formulae IA, IB and IC as defined herein. Optionally, the antibacterial compounds can be bonded to a delivery agent that is capable of bonding to one or more structures on a bacterial cell membrane. The invention also provides the use of such compounds in treating or preventing bacterial infections, and processes for their synthesis.
Claims16
A compound of formula IA,
- or a pharmaceutically-acceptable salt, solvate or clathrate thereof, wherein:
- R1 represents H, C1-6 alkyl, C1-6 acyl, benzyl or benzoyl;
- AA1, AA2 and AA5 to AA7 each independently represents a proteinogenic or non-proteinogenic amino acid;
- AA3 and AA4 each independently represents a proteinogenic or non-proteinogenic amino acid, diaminopropanoic acid, diaminobutanoic acid, or ornithine;
- R8 represents hydrogen or C1-4 alkyl;
- R9a, represents a proteinogenic or non-proteinogenic amino acid side chain, —CH2—NH2, —(CH2)2—NH2 or —(CH2)3—NH2;
- R10a represents a side chain of an amino acid selected from the group consisting of valine, isoleucine, leucine, methionine, phenylalanine, tyrosine and tryptophan, a hydrophobic non-proteinogenic amino acid side chain, hydrogen, or R10a is linked to the adjacent nitrogen atom to form a proline ring;
- R11a represents a proteinogenic or non-proteinogenic amino acid side chain;
- Z is —O— or —NH—;
- optionally wherein the compound of formula IA is covalently bonded to a delivery agent, which is either capable of covalently bonding to one or more structures on a bacterial cell membrane or comprises a hydrophilic portion capable of otherwise binding to one or more structures on a bacterial cell membrane.
7 more elements
A compound selected from the group consisting of:
- and pharmaceutically-acceptable salts, solvates and clathrates thereof.
Dependencies are inferred from the claim text.