Humanized anti-MUC1* antibodies

A chimeric antigen receptor (CAR) comprising

• (a) an anti-MUC1* antibody fragment wherein the anti-MUC1* antibody fragment comprises a heavy chain variable region and a light chain variable region that has complementarity determining regions (CDRs) in the heavy chain variable region and the light chain variable region as follows:
• CDR1 heavy chain SEQ ID NO:
• 123,
• CDR1 light chain SEQ ID NO:
• 173,
• CDR2 heavy chain SEQ ID NO:
• 127,
• CDR2 light chain SEQ ID NO:
• 177,
• CDR3 heavy chain SEQ ID NO:
• 131, and
• CDR3 light chain SEQ ID NO:
• 181;
• and
• (b) a T cell receptor co-stimulatory domain.