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US 11,897,958 B2Granted
Hybridoma clones, monoclonal antibodies to VSIG-4, and methods of making and using
AssigneeBio-Techne Corporation
InventorsBirte Aggeler, Christine Goetz, Jody Bonnevier, Christopher Carlin Valley, Christopher Hammerbeck, Ernesto Ruben Resnik
Life of this patent
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Abstract
Described herein are monoclonal antibodies that bind to VSIG-4 including antibodies that block the binding of VSIG-4 to SIGLEC-7, compositions including the monoclonal antibodies, and methods of making and using those antibodies and compositions.
Claims19
A method of treating a mammalian cancer comprising exposing a mammal comprising a mammalian cancer cell to a monoclonal antibody that binds to VSIG-4, wherein the monoclonal antibody comprises:
- a heavy chain variable region comprising the three complementarity determining regions (CDRs) of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528902.11 (ATCC Accession No. PTA-124187), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528902.11 (ATCC Accession No. PTA-124187);
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528903.111 (ATCC Accession No. PTA-124188), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528903.111 (ATCC Accession No. PTA-124188);
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528905.11 (ATCC Accession No. PTA-124189), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528905.11 (ATCC Accession No. PTA-124189);
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528906.11 (ATCC Accession No. PTA-124178), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528906.11 (ATCC Accession No. PTA-124178);
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528908.11 (ATCC Accession No. PTA-124179), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528908.11 (ATCC Accession No. PTA-124179);
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528910.111 (ATCC Accession No. PTA-124180), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528910.111 (ATCC Accession No. PTA-124180);
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528912.11 (ATCC Accession No. PTA-124181), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528912.11 (ATCC Accession No. PTA-124181);
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528922.111 (ATCC Accession No. PTA-124182), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528922.111 (ATCC Accession No. PTA-124182);
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528927.111 (ATCC Accession No. PTA-124183), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528927.111 (ATCC Accession No. PTA-124183);
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Rt x hVSIG4 489509.11 (ATCC Accession No. PTA-124184), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Rt x hVSIG4 489509.11 (ATCC Accession No. PTA-124184);
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Rt x hVSIG4 489517.111 (ATCC Accession No. PTA-124185), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Rt x hVSIG4 489517.111 (ATCC Accession No. PTA-124185);
- or
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Rt x hVSIG4 489518.11 (ATCC Accession No. PTA-124186), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Rt x hVSIG4 489518.11 (ATCC Accession No. PTA-124186).
10 more elements
A method of detecting cancer in a mammal comprising exposing a mammalian cancer cell to a monoclonal antibody that binds to VSIG-4, wherein the monoclonal antibody comprises:
- a heavy chain variable region comprising the three complementarity determining regions (CDRs) of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528902.11 (ATCC Accession No. PTA-124187), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528902.11 (ATCC Accession No. PTA-124187);
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528903.111 (ATCC Accession No. PTA-124188), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528903.111 (ATCC Accession No. PTA-124188);
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528905.11 (ATCC Accession No. PTA-124189), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528905.11 (ATCC Accession No. PTA-124189);
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528906.11 (ATCC Accession No. PTA-124178), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528906.11 (ATCC Accession No. PTA-124178);
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528908.11 (ATCC Accession No. PTA-124179), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528908.11 (ATCC Accession No. PTA-124179);
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528910.111 (ATCC Accession No. PTA-124180), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528910.111 (ATCC Accession No. PTA-124180);
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528912.11 (ATCC Accession No. PTA-124181), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528912.11 (ATCC Accession No. PTA-124181);
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528922.111 (ATCC Accession No. PTA-124182), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528922.111 (ATCC Accession No. PTA-124182);
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528927.111 (ATCC Accession No. PTA-124183), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528927.111 (ATCC Accession No. PTA-124183);
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Rt x hVSIG4 489509.11 (ATCC Accession No. PTA-124184), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Rt x hVSIG4 489509.11 (ATCC Accession No. PTA-124184);
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Rt x hVSIG4 489517.111 (ATCC Accession No. PTA-124185), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Rt x hVSIG4 489517.111 (ATCC Accession No. PTA-124185);
- or
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Rt x hVSIG4 489518.11 (ATCC Accession No. PTA-124186), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Rt x hVSIG4 489518.11 (ATCC Accession No. PTA-124186).
10 more elements
A method of detecting VSIG-4 in a patient sample, the method comprising contacting the patient sample with a monoclonal antibody that binds to VSIG-4, wherein the monoclonal antibody comprises:
- a heavy chain variable region comprising the three complementarity determining regions (CDRs) of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528902.11 (ATCC Accession No. PTA-124187), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528902.11 (ATCC Accession No. PTA-124187);
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528903.111 (ATCC Accession No. PTA-124188), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528903.111 (ATCC Accession No. PTA-124188);
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528905.11 (ATCC Accession No. PTA-124189), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528905.11 (ATCC Accession No. PTA-124189);
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528906.11 (ATCC Accession No. PTA-124178), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528906.11 (ATCC Accession No. PTA-124178);
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528908.11 (ATCC Accession No. PTA-124179), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528908.11 (ATCC Accession No. PTA-124179);
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528910.111 (ATCC Accession No. PTA-124180), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528910.111 (ATCC Accession No. PTA-124180);
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528912.11 (ATCC Accession No. PTA-124181), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528912.11 (ATCC Accession No. PTA-124181);
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528922.111 (ATCC Accession No. PTA-124182), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528922.111 (ATCC Accession No. PTA-124182);
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Ms x hVSIG4 528927.111 (ATCC Accession No. PTA-124183), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Ms x hVSIG4 528927.111 (ATCC Accession No. PTA-124183);
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Rt x hVSIG4 489509.11 (ATCC Accession No. PTA-124184), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Rt x hVSIG4 489509.11 (ATCC Accession No. PTA-124184);
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Rt x hVSIG4 489517.111 (ATCC Accession No. PTA-124185), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Rt x hVSIG4 489517.111 (ATCC Accession No. PTA-124185);
- or
- a heavy chain variable region comprising the three CDRs of the heavy chain of a monoclonal antibody produced by Rt x hVSIG4 489518.11 (ATCC Accession No. PTA-124186), and a light chain variable region comprising the three CDRs of the light chain of a monoclonal antibody produced by Rt x hVSIG4 489518.11 (ATCC Accession No. PTA-124186).
10 more elements
Dependencies are inferred from the claim text.