Anti-ILT4 antibodies and antigen-binding fragments

A polynucleotide comprising a nucleotide sequence encoding a VH, a VL, both a VH and a VL, a heavy chain immunoglobulin, a light chain immunoglobulin, or both a heavy chain and a light chain immunoglobulin of an antibody or antigen-binding fragment thereof that binds human ILT4, wherein the antibody or antigen-binding fragment thereof comprises a heavy chain variable domain comprising:

• a CDR-H1 having an amino acid sequence of GYYWS (SEQ ID NO:
• 16), a CDR-H2 having an amino acid sequence of EINHSGSTNYNPSLKS (SEQ ID NO:
• 47) or EINHAGSTNYNPSLKS (SEQ ID NO:
• 48), and a CDR-H3 having an amino acid sequence of LPTRWVTTRYFDL (SEQ ID NO:
• 18);
• and a light chain variable domain comprising:
• a CDR-L1 having an amino acid sequence of TGSSSNIGAGYDVH (SEQ ID NO:
• 19), a CDR-L2 having an amino acid sequence of GNSNRPS(SEQ ID NO:
• 49), GQSNRPS(SEQ ID NO:
• 50), GESNRPS(SEQ ID NO:
• 51), GDSNRPS(SEQ ID NO:
• 52), GNANRPS(SEQ ID NO:
• 53), GQANRPS(SEQ ID NO:
• 54), GEANRPS(SEQ ID NO:
• 55), or GDANRPS(SEQ ID NO:
• 56), and a CDR-L3 having an amino acid sequence of QSFDNSLSAYV (SEQ ID NO:
• 21).