Osteopontin monoclonal antibodies
AssigneesAugusta University Research Institute, Inc., Department of Veterans Affairs
InventorsKebin Liu, John Klement, Priscilla S. Redd
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Abstract
Antibodies and antigen binding fragments thereof that immunospecifically bind OPN (OPN) and inhibit OPN activity are provided herein. The disclosed antibodies and antigen binding fragments are useful for modulating signal transduction through OPN proteins. The antibodies and antigen-binding fragments are useful for the treatment or prevention of cancer, osteoporosis, or other immune diseases.
Claims8
A monoclonal antibody or antigen-binding fragment thereof that binds specifically to OPN, wherein the antibody comprises the heavy chain variable region (HCVR) sequences of SEQ ID NO:7, and the light chain variable region (LCVR) of SEQ ID NO:6.
A monoclonal antibody or antigen-binding fragment thereof that binds specifically to OPN, wherein the antibody comprises the heavy chain variable region (HCVR) sequences of SEQ ID NO:9;
- and the light chain variable region (LCVR) of SEQ ID NO:8.
A monoclonal antibody or antigen-binding fragment thereof that binds specifically to OPN, wherein the antibody comprises the heavy chain variable region (HCVR) sequences of SEQ ID NO:11, and the light chain variable region (LCVR) of SEQ ID NO:10.
A monoclonal antibody or antigen-binding fragment thereof that binds specifically to OPN, wherein the antibody comprises the heavy chain variable region (HCVR) sequences of SEQ ID NO:13, and the light chain variable region (LCVR) of SEQ ID NO:12.
Dependencies are inferred from the claim text.