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AssigneeMedImmune, LLC
InventorsDarren Schofield, Matthew Alexander Sleeman, Iain Patrick Chessell, Jonathan Hatcher, David Lowe
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This disclosure provides compositions and methods for controlling pain. In particular the disclosure provides a method for controlling pain comprising co-administration of an NGF antagonist and a TNFα antagonist. The NGF antagonist and the TNFα antagonist can be separate molecules or part of a multifunctional polypeptide, e.g., a multispecific binding molecule that comprises an NGF antagonist domain and a TNFα antagonist domain. This disclosure also provides multifunctional polypeptides, e.g., multispecific binding molecules, comprising an NGF antagonist domain, and a TNFα antagonist domain. The method provides improved pain control. Administration of an NGF antagonist and a TNFα antagonist as provided herein can control pain in the subject more effectively than an equivalent amount of the NGF antagonist or the TNFα antagonist administered alone.
A method for controlling or treating pain in a subject, comprising administering to a subject in need thereof an effective amount of a binding molecule comprising an NGF antagonist domain and a TNFα antagonist domain, wherein the NGF antagonist is an anti-NGF antibody, or antigen-binding fragment thereof;
Dependencies are inferred from the claim text.