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US 11,897,942 B2Granted
Eradication of bacterial biofilm using anti-amyloid monoclonal antibodies
AssigneesTemple University of the Commonwealth System of Higher Education, Lankenau Institute of Medical Research
InventorsCagla Tukel Wilson, Scott Dessain
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Abstract
The present invention features compositions comprising an anti-amyloid antibody and methods of treating microbial infection and treating or preventing microbial biofilms using the composition.
Claims20
A composition comprising a therapeutic antibody, wherein the antibody is specific for binding to an epitope of curli and further wherein the epitope of curli comprises a sequence having homology to an antibody binding site of one or more heterologous amyloid proteins;
- wherein the antibody is a monoclonal antibody selected from the group consisting of:
- a) ALZ.3H3, comprising at least one heavy chain amino acid sequence as set forth in SEQ ID NO:2 and at least one light chain amino acid sequence as set forth in SEQ ID NO:35;
- b) ALZ.4G1, comprising at least one heavy chain amino acid sequence as set forth in SEQ ID NO:61 and at least one light chain amino acid sequence as set forth in SEQ ID NO:63;
- and
- c) ALZ.4A6, comprising at least one of a heavy chain amino acid sequence as set forth in SEQ ID NO:57 and at least one light chain amino acid sequence as set forth in SEQ ID NO:59.
2 more elements
Dependencies are inferred from the claim text.