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US 11,897,941 B2Granted
Compositions and methods for reducing bacterial aggregation
AssigneesLa Trobe University, The University of Queensland
InventorsBegona Heras, Jason Paxman, Mark Schembri, Alvin Lo
Life of this patent
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Abstract
The present disclosure relates to compositions and methods for inhibiting bacterial aggregation, and in particular, to compositions and methods that inhibit autotransporter-mediated bacterial aggregation or attachment. Described herein are autotransporter binding molecules such as antibodies and antigen binding fragments thereof. The autotransporter binding molecules block self-association between autotransporters and autotransporter-mediated surface attachment.
Claims14
An isolated antibody or antigen binding fragment thereof comprising:
- a) a CDRH1 comprising the sequence set forth in SEQ ID NO:
- 3;
- a CDRH2 comprising the sequence set forth in SEQ ID NO:
- 4;
- a CDRH3 comprising the sequence set forth in SEQ ID NO:
- 5;
- a CDRL1 comprising the sequence set forth in SEQ ID NO:
- 6;
- a CDRL2 comprising the sequence set forth in SEQ ID NO:
- 7;
- and
- a CDRL3 comprising the sequence set forth in SEQ ID NO:
- 8;
- or
- b) a CDRH1 comprising the sequence set forth in SEQ ID NO:
- 15;
- a CDRH2 comprising the sequence set forth in SEQ ID NO:
- 16;
- a CDRH3 comprising the sequence set forth in SEQ ID NO:
- 17;
- a CDRL1 comprising the sequence set forth in SEQ ID NO:
- 18;
- a CDRL2 comprising the sequence set forth in SEQ ID NO:
- 19;
- and
- a CDRL3 comprising the sequence set forth in SEQ ID NO:
- 20.
24 more elements
Dependencies are inferred from the claim text.