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US 11,897,940 B2Granted
Broadly neutralizing anti-HIV-1 antibodies and methods of use thereof
AssigneesThe Rockefeller University, California Institute of Technology
InventorsMichel Nussenzweig, Natalia T. Freund, Pamela J. Bjorkman, Louise Scharf
Life of this patent
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Abstract
This invention relates to broadly neutralizing and potent anti-HIV-1 antibodies, kits, and methods of use thereof.
Claims9
An isolated nucleic acid encoding an anti-HIV antibody or antigen binding portion thereof comprising:
- (i) a heavy chain variable region that comprises three heavy chain complementarity determining regions (CDRH 1, CDRH 2, and CDRH 3), wherein the CDRH 1, CDRH 2 and CDRH 3 comprise the respective sequences of SEQ ID NOs:
- 10-12, and
- (ii) a light chain variable region that comprises three light chain complementarity determining regions (CDRL 1, CDRL 2 and CDRL 3), wherein the CDRL 1, CDRL 2 and CDRL 3 comprise the respective sequences of SEQ ID NOs:
- 14-16.
1 more element
Dependencies are inferred from the claim text.