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AssigneesThe University of North Carolina at Chapel Hill, The Johns Hopkins University
InventorsSamuel Lai, Ying-Ying Wang, Arthi Kannan, Kenetta Nunn, Durai Babu Subramani, Richard Cone, Bing Yang, Justin Mccallen
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The presently-disclosed subject matter relates to antibodies, compositions, and methods for inhibiting and treating virus infection in the respiratory tract and virus transmission through the respiratory tract. In particular, the presently-disclosed subject matter relates to inhibiting and treating virus infection in a subject using compositions and antibodies that trap viruses in mucus of the respiratory tract, thereby inhibiting transport of virus across or through mucus secretions.
A method for immobilizing or inhibiting a sexually transmitted infection by a pathogen, or reducing pathogen load in a subject in need thereof, the method comprising administering to a mucosal surface of the subject a recombinant antibody with a specific affinity for the pathogen, the recombinant antibody comprising a human or humanized Fc region, wherein the recombinant antibody comprises a population of antibodies in which at least 40% comprise an oligosaccharide having a GOF glycosylation pattern comprising a biantennary core glycan structure of Manα1-6(Manα1-3)Manβ1-4GlcNAcβ1-4GlcNAcβ1 with a fucose residue and a terminal N-acetylglucosamine, wherein the terminal N-acetylglucosamine is on each branch, that enhances the trapping potency of the recombinant antibody in mucus, so that the recombinant antibody binds to the pathogen to form an antibody/pathogen complex that is trapped in the subject's mucus.
A method of immobilizing a sexually transmitted pathogen in mucus of a subject's reproductive tract, the method comprising administering to the subject, via a topical route, a population of recombinant antibodies with a specific affinity for the pathogen, the recombinant antibodies comprising a human or humanized Fc region, wherein at least 40% of the recombinant antibodies comprise an oligosaccharide having a glycosylation pattern comprising the biantennary core glycan structure Manα1-6(Manα1-3)Manβ1-4GlcNAcβ1-4GlcNAcβ1 with a fucose and a terminal N-acetylglucosamine, wherein the terminal N-acetylglucosamine is on each branch to enhance the trapping potency of the recombinant antibody in mucus, so that the recombinant antibodies bind to the pathogen to form an antibody/pathogen complex that is trapped in the subject's mucus.
A method for inhibiting a sexually transmitted pathogen in mucus of a subject's reproductive tract, the method comprising immobilizing the pathogen by administering to the subject a population of recombinant antibody in which at least 40% comprise an oligosaccharide having a GOF glycosylation pattern comprising a biantennary core glycan structure of Manα1-6(Manα1-3)Manβ1-→GlcNAcβ1-4GlcNAcβ1 with a fucose reside and a terminal N-acetylglucosamine, wherein the terminal N-acetylglucosamine is on each branch, wherein the recombinant antibody has a specific affinity for the pathogen so that the recombinant antibody is trapped in the subject's mucus, the recombinant antibody comprising a human or humanized Fc region, wherein the recombinant antibody comprises an oligosaccharide having a glycosylation pattern that enhances the trapping potency of the recombinant antibody in mucus.
Dependencies are inferred from the claim text.