Factor VIII proteins having ancestral sequences, expression vectors, and uses related thereto
AssigneesEmory University, Georgia Tech Research Corporation
InventorsH. Trent Spencer, Christopher B. Doering, Philip M. Zakas, Eric Gaucher
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Abstract
This disclosure relates to recombinant or chimeric FVIII proteins, variants, and vectors encoding the proteins containing one or more ancestral mutations. In certain embodiments, one or more protein domains comprise amino acid sequences that are derived from ancestrally reconstructed amino acid sequences. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising the proteins or vectors and related methods of inducing blood clotting.
Claims9
A vector comprising a promotor nucleic acid sequence in operable combination with a heterologous nucleic acid sequence encoding a polypeptide selected from the group consisting of SEQ ID NO:
- 20, SEQ ID NO:
- 2, SEQ ID NO:
- 30 and SEQ ID NO:
- 11.
Dependencies are inferred from the claim text.