Immunogenic compositions comprising Mycobacterium tuberculosis polypeptides and fusions thereof
AssigneeAccess To Advanced Health Institute
InventorsSteven G. Reed, Rhea N. Coler, Gregory C. Ireton, Sylvie Bertholet
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Abstract
The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp.) antigens, and polynucleotides encoding such compositions and fusion proteins. The invention also relates to methods for their use in the treatment, prevention and/or diagnosis of tuberculosis infections.
Claims12
A method for stimulating an immune response comprising administering to a subject an effective amount of a composition comprising two or more Mycobacterium tuberculosis antigens, wherein the two or more antigens comprise the antigen Rv3478 comprising the amino acid sequence set forth in SEQ ID NO:
- 41, the antigen Rv3619 comprising the amino acid sequence set forth in SEQ ID NO:46, the antigen Rv2389 comprising the amino acid sequence set forth in SEQ ID NO:
- 21, and the antigen Rv1886 comprising the amino acid sequence set forth in SEQ ID NO:
- 145 or an antigen comprising an amino acid sequence having at least 90% sequence identity to the amino acid sequence set forth in SEQ ID NO:
- 41, an antigen comprising an amino acid sequence having at least 90% sequence identity to the amino acid sequence set forth in SEQ ID NO:
- 46, an antigen comprising an amino acid sequence having at least 90% sequence identity to the amino acid sequence set forth in SEQ ID NO:
- 21, and an antigen comprising an amino acid sequence having at least 90% sequence identity to the amino acid sequence set forth in SEQ ID NO:
- 145;
- and wherein the two or more antigens are covalently linked in the form of a fusion polypeptide.
Dependencies are inferred from the claim text.