Back to results
US 11,897,898 B2Granted
Pyridine macrocycle compounds as ASK1 inhibiting agents
AssigneeBiogen MA Inc.
InventorFelix Gonzalez Lopez de Turiso
Life of this patent
Estimating the term…
Abstract
Provided are compounds of Formula (I′), including compounds of Formulas (I), (II), (III), (IIIA) and (IIIB), wherein L, R1, R3 and n are as defined herein, and pharmaceutically acceptable salts thereof, and methods for their use and production. These compounds can be useful, e.g., in the treatment of disorders responsive to the inhibition of apoptosis signal-regulating kinase 1 (ASK1).
Claims21
A compound of Formula (F):
- or a pharmaceutically acceptable salt thereof, wherein:
- n is selected from 0, 1 and 2;
- L is selected from C3-5 alkylene and C3-5 alkenylene, wherein said C3-5 alkylene and C3-5 alkenylene are optionally substituted with one or two R2;
- R1 in each occurrence is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, carbocyclyl, heterocyclyl, halo, —CN, —C(O)R1a, —C(O)OR1a, —C(O)N(R1a)2, —N(R1a)2, —N(R1a)C(O)R1a, —N(R1a)C(O)OR1a, —N(R1a)C(O)N(R1a)2, —N(R1a)S(O)2R1a, —OR1a, —OC(O)R1a, —OC(O)N(R1a)2, —SR1a, —S(O)R1a, —S(O)2R1a, —S(O)N(R1a)2, and —S(O)2N(R1a)2, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, carbocyclyl, and heterocyclyl, are optionally and independently substituted with one or more R10;
- R1a in each occurrence is independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6alkynyl, carbocyclyl, and heterocyclyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, carbocyclyl, and heterocyclyl in each occurrence are optionally and independently substituted with one or more R10;
- R10 in each occurrence is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, carbocyclyl, heterocyclyl, halo, —CN, —C(O)R10a, —C(O)OR10a, —C(O)N(R10a)2, —N(R10a)2, —N(R10a)C(O)R10a, —N(R10a)C(O)OR10a, —N(R10a)C(O)N(R10a)2, —N(R10a)S(O)2R10a, —OR10a, —OC(O)R10a, —OC(O)N(R10a)2, —SR10a, —S(O)R10a, —S(O)2R10a, —S(O)N(R10a)2, and —S(O)2N(R10a)2, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, carbocyclyl, and heterocyclyl in each occurrence are optionally and independently substituted with one or more halo, —CN, —C(O)R10a, —C(O)OR10a, —C(O)N(R10a)2, —N(R10a)2, —N(R10a)C(O)R10a, —N(R10a)C(O)OR10a, N(R10a)C(O)N(R10a)2, —N(R10a)S(O)2RR10a, —OR10a, —OC(O)R10a, —OC(O)N(R10a)2, —SR10a, —S(O)R10a, —S(O)2R10a, —S(O)N(R10a)2, and —S(O)2N(R10a)2;
- R10a in each occurrence is independently selected from H, C1-6alkyl, C2-6 alkenyl, C2-6alkynyl, carbocyclyl, and heterocyclyl;
- R2 in each occurrence is independently selected from C1-6alkyl, —CN, —C(O)R2a, —C(O)OR2a, —C(O)N(R2a)2, —NO2, —N(R2a)2, —N(R2a)C(O)R2a, —N(R2a)C(O)OR2a, —N(R2a)C(O)N(R2a)2, —N(R2a)S(O)2R2a, —OR2a, —OC(O)R2a, —OC(O)N(R2a)2, —SR2a, —S(O)R2a, —S(O)2R2a, —S(O)N(R2a)2, and —S(O)2N(R1a)2, wherein said C1-6 alkyl is optionally substituted with one or more R20;
- R2a in each occurrence is independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6alkynyl, carbocyclyl, and heterocyclyl wherein said C1-6 alkyl, C2-6 alkenyl, C2-6alkynyl, carbocyclyl, and heterocyclyl in each occurrence are optionally and independently substituted with one or more R20;
- and
- R20 in each occurrence is independently selected from C1-6 alkyl, halo and —OR20a;
- R20a in each occurrence is independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6alkynyl, carbocyclyl, and heterocyclyl;
- and
- R3 is H or C1-4 alkyl.
11 more elements
Dependencies are inferred from the claim text.