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US 11,897,889 B2Granted
Process and intermediates for preparing a JAK1 inhibitor
AssigneeIncyte Corporation
InventorsJiacheng Zhou, Shili Chen, Pingli Liu, David J. Meloni, Yongchun Pan, Naijing Su, Michael Xia
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Abstract
The present invention is related to processes for preparing itacitinib, or a salt thereof, and related synthetic intermediates related thereto.
Claims69
A process of preparing itacitinib, or a salt thereof, comprising:
- reacting a compound of formula 3:
- or a salt thereof, with a reagent selected from (i) a salt of formula 2a, or a salt thereof, and (ii) a compound of formula 2b:
- wherein X− is a counter anion.
A process of preparing itacitinib, or a salt thereof, comprising:
- reacting a compound of formula 3:
- or a salt thereof, with a reagent selected from (i) a salt of formula 2a, and (ii) a compound of formula 2b:
- wherein X− is a counter anion.
A process of preparing itacitinib, or a salt thereof, comprising reacting a salt of formula 2c:
- with a compound of formula 3:
- or a salt thereof, to form the itacitinib, or the salt thereof.
A compound of formula 3, having the formula:
- or a salt thereof.
Dependencies are inferred from the claim text.