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US 11,897,888 B1Granted
Small molecular inhibitors of sting signaling compositions and methods of use
AssigneeStinginn LLC
InventorGlen N Barber
Life of this patent
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Abstract
Compounds of the present application or pharmaceutically acceptable salts thereof are capable of interacting with and attenuating the activity of a stimulator of interferon genes (STING) protein. In an embodiment of the invention, antagonist compounds bind to STING protein and attenuate STING downstream signaling. Pharmaceutical compositions and methods involving such compounds as STING modulators are additionally provided herein.
Claims13
A compound of Formula I:
- or a pharmaceutically acceptable salt, hydrate, ester, stereoisomer, or tautomer thereof, where R1 is —(C2-C6) alkyl-(C3-C6) cycloalkenyl, —(C1-C6) alkyl-(C3-C6) cycloalkyl, —(C1-C6) alkyl-(C3-C6) substituted cycloalkenyl, —(C1-C6) alkoxy-(C3-C6) cycloalkenyl, —(C2-C6) alkenyl-(C3-C6) cycloalkenyl, where R2, R3, R4, R5 and R6 are independently selected from the group consisting of —H, -halogen, —(C1-C6) alkyl, —(C3-C6) cycloalkyl, —(C1-C6) haloalkyl, —(C1-C6) alkoxy, C6) haloalkoxy, —(C2-C6) alkenyl, — (C2-C6) alkynyl, -nitro, —CN, —OH, —COOH, —SH, —NH2, —NH(C1-C4) alkyl, and —N((C1-C4) alkyl)2, where R7 is the atom selected from the group consisting of selenium and oxygen.
Dependencies are inferred from the claim text.