sGC stimulators

A compound of Formula I, or a pharmaceutically acceptable salt thereof,

• wherein:
• Y is independently N or C;
• ring B is a phenyl or a 5 or 6-membered heteroaryl ring, containing 1 or 2 ring heteroatoms independently selected from N, O and S;
• n is an integer selected from 0 to 3;
• and each JB is independently halogen, —CN, a C1-6 aliphatic or —ORB;
• wherein each JB that is a C1-6 aliphatic is optionally and independently substituted with up to 3 instances of R3;
• each RB is independently hydrogen or a C1-6 aliphatic;
• said C1-6 aliphatic represented by RB is optionally and independently substituted with up to 3 instances of R3a;
• each R3 and R3a is, in each instance, independently halogen, —CN, C1-4 alkyl, C1-4 haloalkyl, —O(C1-4 alkyl) or —O(C1-4 haloalkyl);
• Z is selected from the group consisting of hydrogen, —P(O)(OH)2, —P(O)(OH)O−M+, —P(O)(O−)2 (M+)2, —P(O)(O−)2 D2+and —P(O)(O-Benzyl)2;
• wherein M+ is a pharmaceutically acceptable monovalent cation and D2+is a pharmaceutically acceptable divalent cation;
• m is 0 or 1;
• R1 is C1-4 alkyl, C1-4 fluoroalkyl, —C(O)NH2 or hydrogen;
• and
• R2 is C1-4 alkyl, C1-4 fluoroalkyl or hydrogen;
• both instances of R4 are simultaneously hydrogen or both instances of R4, together with the carbon atom to which they are attached form a carbonyl group;
• JD is hydrogen, halogen, methoxy or —CN
• p is 1 or 2;
• and
• each JC is independently hydrogen, halogen, C1-4 aliphatic, C1-4 alkoxy or —CN;
• wherein each said C1-4 aliphatic and each said C1-4 alkoxy is optionally and independently substituted by up to 3 instances of C1-4 alkoxy, C1-4 haloalkoxy, —OH or halogen.