Indazole amine derivative, preparation method therefor and medical use thereof

A compound of formula (I), or stereoisomers, tautomers or pharmaceutically acceptable salts thereof:

• wherein:
• R1 and R2 are independently selected from hydrogen or C 1-C6 alkyl;
• R3 is selected from halogen, cyano, carboxyl, —CONRARB, haloalkyl or heteroaryl;
• wherein the heteroaryl is optionally further substituted by one or more substituents selected from halogen, hydroxyl, cyano, carboxyl, —CONRARB or haloalkyl;
• W is azetidinyl, nitrogen-containing aromatic heterocyclic ring group or nitrogen-containing aromatic heterocyclic ring group bonded via a single methylene group;
• wherein the azetidinyl is optionally further substituted by one or more substituents selected from —CORC, —SO2RD, C1-C6 alkyl or C 3-C6 cycloalkyl;
• wherein the nitrogen-containing aromatic heterocyclic ring group is optionally further substituted by one or more substituents selected from halogen, cyano, carboxyl, —CONRARB and haloalkyl;
• or, W has a structure of formula (II):
• * represents bonding site of the group to rest of the molecule;
• Ra is selected from hydrogen, C 1-C6 alkyl or C 3-C6 cycloalkyl;
• wherein the C 1-C6 alkyl or C 3-C6 cycloalkyl is optionally further substituted by one or more substituents selected from halogen, hydroxyl, carboxyl and —SO2NRERF;
• Rb and Rc are independently selected from hydrogen, —CORC, —SO2RD, C1-C6 alkyl or C3-C6 cycloalkyl;
• or, any two of R a, R b and Rc together with the atoms to which they are attached form a 4-8 membered nitrogen-containing heterocyclic ring, wherein the nitrogen-containing heterocyclic ring may be further substituted by one or more oxo groups (O═);
• RA, R B, R E and R F are independently selected from hydrogen, C1-C6 alkyl or C3-C6 cycloalkyl;
• wherein the alkyl or cycloalkyl is optionally further substituted by one or more substituents selected from halogen, hydroxyl, cyano or haloalkyl;
• RC and R D are independently selected from C1-C6 alkyl or C 3-C6 cycloalkyl;
• wherein the alkyl or cycloalkyl is optionally further substituted by one or more substituents selected from halogen, hydroxyl, cyano or haloalkyl.