Isotopically-stabilized tetronimide compounds

A method of treating one or more conditions associated with a disease selected from the group consisting of hypercholesterolemia, a viral disease, and blood coagulation disorders,

• by administering one or more doses of
• a pharmaceutical composition comprising one or more deuterated compounds of Formulas {I-A}, {I-B}, {I-C}, {I-D}, {I-E}, {I-F}, I-G}, or {I-H}:or one or more pharmaceutically-acceptable esters, metabolites, prodrugs, or solvates thereof and a pharmaceutically-acceptable carrier
• in one or more amounts effective to treat one or more conditions associated said disease;
• wherein at least one deuterated compound is represented by any one of the following Formulas:
• or a salt, ester, metabolite, prodrug, or solvate thereof,
• wherein Ar1 is a substituted or unsubstituted C6-C20 aryl or 5- to 20-membered heteroaryl;
• wherein at least one of V1, V2, V3, V4, V5, or Z1, Z2, Z3, Z4, Z5, Z6, Z7, Z8, or Z9 is a deuterium atom (D) and any atom not designated as deuterium is present as hydrogen (H, or not shown) at its natural isotopic abundance;
• wherein W is C(O), C(S), or S(O)2;
• wherein Y is a single bond, O, CR50R51, or NR52 when W is CO and Y is a single bond, CR50R51 or NR52 when W is SO2;
• wherein R53 is selected from the group consisting of substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C2-C6 alkenyl, substituted or unsubstituted C2-C6 alkynyl, substituted or unsubstituted C6-C20 aryl, substituted or unsubstituted C7-C26 arylalkyl, substituted or unsubstituted 5 to 20-membered heteroaryl, and substituted or unsubstituted 6-26 membered heteroarylalkyl;
• and
• wherein Ar2, designated as an unsubstituted or substituted C6-C20 heteroaryl is selected from the group consisting of:
• phenyl;
• naphthyl;
• pyridyl;
• pyridine;
• pyridone;
• pyrimidine;
• pyradazine;
• pyrazine;
• purine;
• furan;
• thiophene;
• oxazole;
• thiazole;
• isoxazole;
• isothiazole;
• oxadiazole;
• thiadiazole;
• pyrrole;
• imidazole;
• triazole;
• tetrazole;
• and diazepine.