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US 11,897,852 B2Granted
Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same
AssigneeThe University of Toledo
InventorsBruce E. Heck, Dong Hyun Kim, Paul W. Erhardt, Brian Kress
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Abstract
Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.
Claims6
A method of treating osteoarthritis by inducing chondrogenesis in a subject having osteoarthritis, the method comprising:
- administering an effective amount of a pharmaceutical composition to the subject in need thereof sufficient to induce chondrogenesis;
- the pharmaceutical composition comprising a peroxisome proliferator activated receptor (PPAR) compound in an amount sufficient to prompt stem cells in the subject to contribute toward improving cartilage health, and a pharmaceutically acceptable carrier, excipient, diluent or adjuvant;
- wherein the PPAR compound has a chemical structure of Formula (12d):
- wherein:
- X is S;
- R1 is CF3;
- R2 is F;
- and
- R3 is H;
- and,
- salts, isomers, solvates, hydrates, polymorphs and prodrugs thereof.
8 more elements
A method of treating a mammalian patient in need thereof, the method comprising:
- administering induced stem cells to a mammalian patient in need thereof;
- wherein the induced stem cells are derived from incubating stem cells with a pharmaceutical composition comprising a peroxisome proliferator activated receptor (PPAR) compound in an amount sufficient to prompt stem cells in the patient to contribute toward improving cartilage health and inducing chondrogenesis, and a pharmaceutically acceptable carrier, excipient, diluent or adjuvant;
- wherein the PPAR compound has a chemical structure of Formula (12d):
- wherein:
- X is S;
- R1 is CF3;
- R2 is F;
- and
- R3 is H;
- and,
- salts, isomers, solvates, hydrates, polymorphs and prodrugs thereof.
8 more elements
Dependencies are inferred from the claim text.