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US 11,897,851 B2Granted
Heterocyclic GLP-1 agonists
AssigneeGasherbrum Bio, Inc.
InventorsQinghua Meng, Hui Lei, Haizhen Zhang, Xichen Lin, Andrew Jennings
Life of this patent
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Abstract
This disclosure relates to GLP-1 agonists of Formula I: including pharmaceutically acceptable salts and solvates thereof, and pharmaceutical compositions including the same.
Claims5
A compound of Formula (I-A4-1), or a pharmaceutically acceptable salt thereof:
- wherein:
- is a single bond or a double bond;
- R0-1 is selected from the group consisting of hydrogen and (C1-C3)alkyl;
- X4 is selected from the group consisting of N and CRy;
- Ry is selected from the group consisting of hydrogen, —OH, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy, (C1-C6)haloalkoxy, CN, and halogen;
- T2 is (C1-C3)alkyl which is substituted with a substituent selected from the group consisting of (C1-C3)alkoxy, S(O)2(C1-C3 alkyl), (C3-C6)cycloalkyl, 3- to 6-membered heterocycloalkyl, phenyl, and 5- to 6-membered heteroaryl, wherein the phenyl or 5- to 6-membered heteroaryl are each optionally substituted with halogen or (C1-C3)alkyl;
- Raa is selected from the group consisting of hydrogen and (C1-C3)alkyl;
- Ring C is selected from the group consisting of phenyl and 6-membered heteroaryl;
- b is 0, 1, or 2;
- and
- each occurrence of Rb is independently selected from the group consisting of (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy, (C1-C6)haloalkoxy, halogen, and CN.
8 more elements
Dependencies are inferred from the claim text.