Mesoporous nitric oxide-releasing silica particles, methods of making, and uses thereof

A nitric oxide-releasing material consisting of:

• a mesoporous silica core having an outer surface, and
• a plurality of moieties having a structure according to the following formula covalently bonded to the outer surface of the mesoporous silica core
• where A is a S-nitrosothiol selected from the group consisting of S-nitroso-N-acetyl-penicillamine, S-nitroso-N-acetyl cysteine, S-nitroso-N-acetyl cysteamine, S-nitrosoglutathione, and methyl S-nitrosothioglycolate;
• where R1 is a substituted or unsubstituted C1-C20 alkyl, a substituted or unsubstituted C1-C20 heteroalkyl, a substituted or unsubstituted C2-C20 alkenyl, a substituted or unsubstituted C2-C20 herteroalkenyl, a substituted or unsubstituted C1-C20 alkoxy, or a substituted or unsubstituted C1-C20 heteroalkoxy;
• where each occurrence of R2 is independently a substituted or unsubstituted C1-C20 alkyl, a substituted or unsubstituted C1-C20 heteroalkyl, a substituted or unsubstituted C2-C20 alkenyl, a substituted or unsubstituted C2-C20 herteroalkenyl, a substituted or unsubstituted C1-C20 alkoxy, a substituted or unsubstituted C1-C20 heteroalkoxy, or a bond to an oxygen atom on the outer surface so long as at least one occurrence of R2 is a bond to an oxygen atom on the outer surface of the mesoporous silica core.